Tablet presses are mainly used for tablet process research in the pharmaceutical industry. The tablet press is an automatic continuous production equipment for compressing the granules into round, special-shaped and sheet-like objects with characters, symbols and graphics with a diameter of not more than 13mm.
The models can be divided into single punch tablet press, flower basket tablet press, rotary tablet press, sub-high-speed rotary tablet press, automatic high-speed tablet press and rotary core-spun tablet press.
The principle of tableting machine:
①Dose control. Various tablets have different dosage requirements. Large dosage adjustment is achieved by selecting punches with different punch diameters, such as punches with diameters of 6mm, 8mm, 11.5mm, and 12mm.
After the die size is selected, the small dose adjustment is by adjusting the depth of the lower punch extending into the middle die hole, thereby changing the actual length of the middle die hole after back sealing, and adjusting the filling volume of the drug in the die hole.
Therefore, there should be a mechanism for adjusting the original position of the lower punch in the die hole on the tablet press to meet the dosage adjustment requirements.
Due to the difference in specific volume between different batches of powder preparations, this adjustment function is very necessary.
In the dose control, the action principle of the feeder also has a considerable influence.
For example, the granular drug relies on its own weight, and when it freely rolls into the middle die hole, its filling condition is relatively loose.
If multiple forced entry methods are used, more drugs will be filled in the die holes, and the filling situation will be more dense.
②Control of tablet thickness and compaction degree. The dosage of the drug is determined according to the prescription and pharmacopoeia and cannot be changed.
For the time limit of storage, preservation and disintegration, the pressure of a certain dose is also required during tableting, which will also affect the actual thickness and appearance of the tablet. Pressure regulation during tableting is guaranteed.
This is achieved by adjusting the downward amount of the punch in the die hole.
Some tablet presses not only have the upward and downward movements of the upper and lower punches during the tableting process, but also have the upper and lower movements of the lower punches, and the relative movement of the upper and lower punches completes the tableting process.
However, the pressure regulation is mostly realized by the mechanism of adjusting the upward and downward flow to realize the pressure regulation and control.
